TargetMol

SJFδ

Product Code:
 
TAR-T18682
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18682-100mg100mgEnquire
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TAR-T18682-500mg500mgEnquire
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Further Information

Bioactivity:
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
CAS:
2254609-23-7
Molecular Weight:
1168.27
Purity:
0.98
SMILES:
C(NC1=CC(F)=C(OC=2C3=C(C=C(OCCOCCOCCOC4=C(CNC(=O)[C@H]5N(C([C@H](C(C)C)N6CC=7C(C6=O)=CC=CC7)=O)C[C@H](O)C5)C=CC(=C4)C=8SC=NC8C)C(OC)=C3)N=CC2)C=C1)(=O)C9(C(NC%10=CC=C(F)C=C%10)=O)CC9

References

Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.