TargetMol

O-Desmethyl apixaban sulfate sodium

Product Code:
 
TAR-T19488
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 uM,and is a major circulating metabolite of Apixaban in humans.
CAS:
T19488
Molecular Weight:
547.52
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=C(C1=NN(C2=CC=C(OS(=O)(O[Na])=O)C=C2)C3=C1CCN(C4=CC=C(N5C(CCCC5)=O)C=C4)C3=O)N
Target:
Factor Xa

References

Wong PC, et al. Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor. J Thromb Thrombolysis. 2011 May;31(4):478-92. Wang L, et al. Sulfation of o-demethyl apixaban: enzyme identification and species comparison. Drug Metab Dispos. 2009 Apr;37(4):802-8.