TargetMol

Desethylamiodarone

Product Code:
 
TAR-T20659
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Diethylamiodarone is the main metabolite of amiodarone in vivo.
CAS:
83409-32-9
Molecular Weight:
617.26
Purity:
0.98
SMILES:
O=C(C1=CC(I)=C(OCCNCC)C(I)=C1)C=2C=3C=CC=CC3OC2CCCC

References

Hong LX, Ying YC, Lei Z, Chen GR. Preparation and determination of desethylamiodarone in dog lung by HPLC-MS. Pharmazie. 2011 Nov;66(11):822-5. PubMed PMID: 22204125. Khurana R, Bin Jardan YA, Wilkie J, Brocks DR. Breast milk concentrations of amiodarone, desethylamiodarone, and bisoprolol following short-term drug exposure: two case reports. J Clin Pharmacol. 2014 Jul;54(7):828-31. doi: 10.1002/jcph.272. Epub 2014 Feb 5. PubMed PMID: 24482268. Ghovanloo MR, Abdelsayed M, Ruben PC. Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels. Front Pharmacol. 2016 Mar 1;7:39. doi: 10.3389/fphar.2016.00039. eCollection 2016. PubMed PMID: 26973526; PubMed Central PMCID: PMC4771766. Morvay N, Baczk? I, Sztojkov-Ivanov A, Falkay G, Papp JG, Varr? A, Lepr?n I. Long-term pretreatment with desethylamiodarone (DEA) or amiodarone (AMIO) protects against coronary artery occlusion induced ventricular arrhythmias in conscious rats. Can J Physiol Pharmacol. 2015 Sep;93(9):773-7. doi: 10.1139/cjpp-2014-0530. Epub 2015 Apr 2. PubMed PMID: 26176275.