TargetMol

Deutetrabenazine metabolite M4

Product Code:
 
TAR-T23983
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T23983-100mg100mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23983-500mg500mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Deutetrabenazine metabolite M4 is believed to be related to its effect as a reversible depletion of monoamines from nerve terminals. The major circulating metabolites of Deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake of monoamines into synaptic vesicles and depletion of monoamine stores.
CAS:
1688661-95-1
Molecular Weight:
339.46
Purity:
0.98
SMILES:
O(C([2H])([2H])[2H])C=1C=C2[C@]3(N(C[C@H](CC(C)(C)O)C(=O)C3)CCC2=CC1OC([2H])([2H])[2H])[H]

References

Geschwind MD, Paras N. Deutetrabenazine for Treatment of Chorea in Huntington Disease. JAMA. 2016 Jul 5;316(1):33-5. doi: 10.1001/jama.2016.8011. PubMed PMID: 27380339. Jankovic J, Jimenez-Shahed J, Budman C, Coffey B, Murphy T, Shprecher D, Stamler D. Deutetrabenazine in Tics Associated with Tourette Syndrome. Tremor Other Hyperkinet Mov (N Y). 2016 Nov 7;6:422. eCollection 2016. PubMed PMID: 27917309; PubMed Central PMCID: PMC5133390. Reilmann R. Deutetrabenazine-Not a Revolution but Welcome Evolution for Treating Chorea in Huntington Disease. JAMA Neurol. 2016 Dec 1;73(12):1404-1406. doi: 10.1001/jamaneurol.2016.3916. PubMed PMID: 27749952. Huntington Study Group, Frank S, Testa CM,et al. Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. JAMA. 2016 Jul 5;316(1):40-50. doi: 10.1001/jama.2016.8655. PubMed PMID: 27380342.