TargetMol

eSM156

Product Code:
 
TAR-T24045
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24045-100mg100mgEnquire
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TAR-T24045-500mg500mgEnquire
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Further Information

Bioactivity:
eSM156 is an effective FLT3 inhibitor. It has high antiproliferative activity against acute myeloid leukemia (AML) cells. eSM156 has IC50 (FLT3) = 1.4 nM; EC50 (MV4-11cells) = 150 nM; EC50 (MOLM-13 cells) = 40 nM.
CAS:
T24045
Molecular Weight:
405.55
Purity:
0.98
SMILES:
CNC1=NC=C2C(N(CC3CCCC3)N=C2C4=CC=C(N5CCN(C)CC5)C=C4)=N1

References

Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening Samuel H. Myers, Carolin Temps, Douglas R. Houston, Valerie G. Brunton, and Asier Unciti-Broceta Publication Date (Web): February 21, 2018 (Brief Article) doi: 10.1021/acs.jmedchem.7b01605