TargetMol

Jadomycin B

Product Code:
 
TAR-T24190
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24190-500mg500mgEnquire
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Further Information

Bioactivity:
A jadomycin is an anacyclic natural product produced by Streptomyces venezuelae ISP5230.
CAS:
149633-99-8
Molecular Weight:
549.576
Purity:
0.98
SMILES:
[H][C@@]1([C@@H](C)CC)N2C(OC1=O)c1cc(C)cc(O)c1C1=C2C(=O)c2c(O[C@H]3C[C@@H](O)[C@@H](O)[C@H](C)O3)cccc2C1=O |c:21|

References

Hall SR, Toulany J, Bennett LG, Martinez-Farina CF, Robertson AW, Jakeman DL, Goralski KB. Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells. J Pharmacol Exp Ther. 2017 Nov;363(2):196-210. doi: 10.1124/jpet.117.241125. Epub 2017 Sep 13. PubMed PMID: 28904004. Li L, Pan G, Zhu X, Fan K, Gao W, Ai G, Ren J, Shi M, Olano C, Salas JA, Yang K. Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase. Appl Microbiol Biotechnol. 2017 Jul;101(13):5291-5300. doi: 10.1007/s00253-017-8256-y. Epub 2017 Apr 20. PubMed PMID: 28429060. Zhu J, Sun D, Liu W, Chen Z, Li J, Wen Y. AvaR2, a pseudo ?-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. Mol Microbiol. 2016 Nov;102(4):562-578. doi: 10.1111/mmi.13479. Epub 2016 Aug 25. PubMed PMID: 27502190. Wang W, Yang T, Li Y, Li S, Yin S, Styles K, Corre C, Yang K. Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts. ACS Synth Biol. 2016 Jul 15;5(7):765-73. doi: 10.1021/acssynbio.6b00087. Epub 2016 May 6. PubMed PMID: 27100123.