TargetMol

L 659874

Product Code:
 
TAR-T24313
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24313-100mg100mgEnquire
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TAR-T24313-500mg500mgEnquire
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Further Information

Bioactivity:
L 659874 is a cyclic hexapeptide. It is also a tachykinin antagonist.
CAS:
125989-15-3
Molecular Weight:
821.98
Purity:
0.98
SMILES:
C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCSC)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3

References

Hall JM, Flowers JM, Morton IK. A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder. Br J Pharmacol. 1992 Nov;107(3):777-84. PubMed PMID: 1282072; PubMed Central PMCID: PMC1907736. Fleetwood-Walker SM, Parker RM, Munro FE, Young MR, Hope PJ, Mitchell R. Evidence for a role of tachykinin NK2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae III-V) neurons. Eur J Pharmacol. 1993 Sep 28;242(2):173-81. PubMed PMID: 8253113. Fan TP, Hu DE, Guard S, Gresham GA, Watling KJ. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol. 1993 Sep;110(1):43-9. PubMed PMID: 7693287; PubMed Central PMCID: PMC2176009. Munro FE, Fleetwood-Walker SM, Parker RM, Mitchell R. The effects of neurokinin receptor antagonists on mustard oil-evoked activation of rat dorsal horn neurons. Neuropeptides. 1993 Nov;25(5):299-305. PubMed PMID: 8115032.