TargetMol

L-368899 free base

Product Code:
 
TAR-T24370
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24370-100mg100mgEnquire
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TAR-T24370-500mg500mgEnquire
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Further Information

Bioactivity:
L-368899 is a non-peptide and orally active antagonist of oxytocin receptor (IC50: 8.9 nM). It displays 40-fold selectivity over vasopressin V1a and V2 receptors (IC50: 370 and 570 nM respectively).
CAS:
148927-60-0
Molecular Weight:
554.77
Purity:
0.98
SMILES:
[H][C@@]12CC[C@@](CS(=O)(=O)N3CCN(CC3)c3ccccc3C)([C@H](C1)NC(=O)[C@@H](N)CCS(C)(=O)=O)C2(C)C |@:35,TLB:24:22:35:2.3|

References

Kang SW, Jayanthi S, Nagarajan G, Suresh Kumar TK, Kuenzel WJ. Identification of avian vasotocin receptor subtype-specific antagonists involved in the stress response of the chicken, Gallus gallus. J Biomol Struct Dyn. 2018 May 17:1-15. doi: 10.1080/07391102.2018.1464957. [Epub ahead of print] PubMed PMID: 29658387. Taylor JH, Cavanaugh J, French JA. Neonatal oxytocin and vasopressin manipulation alter social behavior during the juvenile period in Mongolian gerbils. Dev Psychobiol. 2017 Jul;59(5):653-657. doi: 10.1002/dev.21533. Epub 2017 May 31. PubMed PMID: 28561891; PubMed Central PMCID: PMC5523843. Boulet NP, Cloutier CJ, Ossenkopp KP, Kavaliers M. Oxytocin, social factors, and the expression of conditioned disgust (anticipatory nausea) in male rats. Behav Pharmacol. 2016 Dec;27(8):718-725. PubMed PMID: 27740965. Kotani M, Shimono K, Yoneyama T, Nakako T, Matsumoto K, Ogi Y, Konoike N, Nakamura K, Ikeda K. An eye tracking system for monitoring face scanning patterns reveals the enhancing effect of oxytocin on eye contact in common marmosets. Psychoneuroendocrinology. 2017 Sep;83:42-48. doi: 10.1016/j.psyneuen.2017.05.009. Epub 2017 May 10. PubMed PMID: 28586711.