TargetMol

Y08060

Product Code:
 
TAR-T24411
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24411-100mg100mgEnquire
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TAR-T24411-500mg500mgEnquire
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Further Information

Bioactivity:
Y08060 is an effective and selective BET Inhibitor for the Treatment of Prostate Cancer. Y08060 effectively suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. Y08060 has IC50 values of 3.23 and 4.41 uM in inhibition of cell viability in the C4 2B and LNCaP cell lines, respectively.
CAS:
T24411
Molecular Weight:
471.32
Purity:
0.98
SMILES:
O=S(C1=CC(Br)=CC=C1OC)(NC2=C(OC)C=C(N3)C(OC(C)(C)C3=O)=C2)=O

References

Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer Qiuping Xiang, Yan Zhang, Jiaguo Li, Xiaoqian Xue, Chao Wang, Ming Song, Cheng Zhang, Rui Wang, Chenchang Li, Chun Wu, Yulai Zhou, Xiaohong Yang, Guohui Li, Ke Ding, and Yong Xu Publication Date (Web): February 13, 2018 (Letter) doi: 10.1021/acsmedchemlett.8b00003