TargetMol

Thymidine 3',5'-disphosphate

Product Code:
 
TAR-T24609
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24609-500mg500mgEnquire
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Further Information

Bioactivity:
pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.
CAS:
09/04/2863
Molecular Weight:
402.19
Purity:
0.98
SMILES:
O=C1N([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](OP(=O)(O)O)C2)C=C(C)C(=O)N1

References

Lopez-Zavala AA, Sotelo-Mundo RR, Hernandez-Flores JM, Lugo-Sanchez ME, Sugich-Miranda R, Garcia-Orozco KD. Arginine kinase shows nucleoside diphosphate kinase-like activity toward deoxythymidine diphosphate. J Bioenerg Biomembr. 2016 Jun;48(3):301-8. doi: 10.1007/s10863-016-9660-1. Epub 2016 Apr 12. PubMed PMID: 27072556. Wang CC, Tsong TY, Hsu YH, Marszalek PE. Inhibitor binding increases the mechanical stability of staphylococcal nuclease. Biophys J. 2011 Feb 16;100(4):1094-9. doi: 10.1016/j.bpj.2011.01.011. Erratum in: Biophys J. 2011 Mar 16;100(6):1596. PubMed PMID: 21320455; PubMed Central PMCID: PMC3037565. Jariwala N, Rajasekaran D, Mendoza RG, Shen XN, Siddiq A, Akiel MA, Robertson CL, Subler MA, Windle JJ, Fisher PB, Sanyal AJ, Sarkar D. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316. doi: 10.1158/0008-5472.CAN-17-0298. Epub 2017 Apr 20. PubMed PMID: 28428278; PubMed Central PMCID: PMC5488274. Sunil S, Hossain MJ, Ramasamy G, Malhotra P. Transient silencing of Plasmodium falciparum Tudor Staphylococcal Nuclease suggests an essential role for the protein. Biochem Biophys Res Commun. 2008 Jul 25;372(2):373-8. doi: 10.1016/j.bbrc.2008.05.033. Epub 2008 May 16. PubMed PMID: 18486605.