TargetMol

PF-06807656

Product Code:
 
TAR-T24623
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24623-100mg100mgEnquire
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TAR-T24623-500mg500mgEnquire
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Further Information

Bioactivity:
PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ flux IC50 = 160 nM).
CAS:
T24623
Molecular Weight:
449.91
Purity:
0.98
SMILES:
O=C(NC(C1=NN(C)N=C1)C)C2=CC(S(=O)(NC3=CC=C(Cl)C=C3)=O)=C(OC)C=C2

References

Sammons M F , Kharade S V , Filipski K J , et al. Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.[J]. Acs Medicinal Chemistry Letters, 2018:acsmedchemlett.7b00481.