TargetMol

SK&F 107260

Product Code:
 
TAR-T24796
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24796-100mg100mgEnquire
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TAR-T24796-500mg500mgEnquire
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Further Information

Bioactivity:
SK&F 107260 is an RGD-containing peptide. It is a potent GP IIb/IIIa antagonist and a vitronectin antagonist.
CAS:
136620-00-3
Molecular Weight:
601.7
Purity:
0.98
SMILES:
O=C1C=2C(SSC=3C(NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)N1C)=CC=CC3)=CC=CC2

References

Wong A, Hwang SM, McDevitt P, McNulty D, Stadel JM, Johanson K. Studies on alpha v beta 3/ligand interactions using a [3H]SK&F-107260 binding assay. Mol Pharmacol. 1996 Sep;50(3):529-37. PubMed PMID: 8794891. Samanen J, Wilson G, Smith PL, Lee CP, Bondinell W, Ku T, Rhodes G, Nichols A. Chemical approaches to improve the oral bioavailability of peptidergic molecules. J Pharm Pharmacol. 1996 Feb;48(2):119-35. Review. PubMed PMID: 8935160. Wong A, Hwang SM, Johanson K, Samanen J, Bennett D, Landvatter SW, Chen W, Heys JR, Ali FE, Ku TW, Bondinell W, Nichols AJ, Powers DA, Stadel JM. Binding of [3H]-SK&F 107260 and [3H]-SB 214857 to purified integrin alphaIIbbeta3: evidence for a common binding site for cyclic arginyl-glycinyl-aspartic acid peptides and nonpeptides. J Pharmacol Exp Ther. 1998 Apr;285(1):228-35. PubMed PMID: 9536015. Freed MI, Boike S, Zariffa N, Jorkasky DK. Effect of acetylsalicylic acid on inhibition of ex vivo platelet aggregation and secretion by SKF 107260, a novel GPIIb/IIIa receptor antagonist. Thromb Haemost. 1994 Oct;72(4):622-6. PubMed PMID: 7878642.