TargetMol

Spiraprilat

Product Code:
 
TAR-T24820
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T24820-100mg100mgEnquire
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TAR-T24820-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Spiraprilat is an ACE inhibitor. It also is an active metabolite of spirapril.
CAS:
83602-05-5
Molecular Weight:
438.56
Purity:
0.98
SMILES:
C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2CC3(C[C@H]2C(O)=O)SCCS3

References

Sch?rer M, Erb K, Junge K, Sch?fer HF, Schulz HU, Amschler S, Krupp S, Hermann R. Drug interaction of spirapril hydrochloride monohydrate and hydrochlorothiazide. A clinical study to compare the pharmacokinetics after administration of spirapril hydrochloride monohydrate tablets, hydrochlorothiazide tablets and fixed combination bi-layer tablets. Arzneimittelforschung. 2003;53(6):414-9. PubMed PMID: 12872612. Sramko M, Smiesko M, Remko M. Accurate aqueous proton dissociation constants calculations for selected angiotensin-converting enzyme inhibitors. J Biomol Struct Dyn. 2008 Jun;25(6):599-608. PubMed PMID: 18399693. Sch?rer M, Amschler S, Schulz HU, Sch?fer HF. Simultaneous determination of spirapril and spiraprilat in plasma by capillary gas chromatography-mass spectrometry. Arzneimittelforschung. 2003;53(5):307-13. PubMed PMID: 12854357. Hayduk K, Kraul H. Efficacy and safety of spirapril in mild-to-moderate hypertension. J Cardiovasc Pharmacol. 1999 Aug;34 Suppl 1:S19-23. Review. PubMed PMID: 10499560.