TargetMol

Emofolin sodium

Product Code:
 
TAR-T25374
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity,which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, depletion of nucleotide pools, and inhibition of DNA, RNA and protein synthesis.
CAS:
52386-42-2
Molecular Weight:
496.48
Purity:
0.98
SMILES:
[Na].CN1C(CCNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]c(N)nc(=O)c12

References

Busari AA, Adejare AA, Shodipe AF, Oduniyi OA, Ismail-Badmus KB, Oreagba IA. Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats. Drug Res (Stuttg). 2018 Jun 26. doi: 10.1055/a-0626-7003. [Epub ahead of print] PubMed PMID: 29945276. Adam EH, Zacharowski K, Hintereder G, Raimann F, Meybohm P. Validation of a New Small-Volume Sodium Citrate Collection Tube for Coagulation Testing in Critically Ill Patients with Coagulopathy. Clin Lab. 2018 Jun 1;64(6):1083-1089. doi: 10.7754/Clin.Lab.2018.171008. PubMed PMID: 29945334. Dziadosz M. Adduct Formation-Supported Two-Way Electrospray Ionization Strategy for the Determination of Urinary Creatinine Concentration with LC-MS-MS in Abstinence Control. J Anal Toxicol. 2018 Jun 26. doi: 10.1093/jat/bky042. [Epub ahead of print] PubMed PMID: 29945182. Liu M, Zhang G, Zheng C, Song M, Liu F, Huang X, Bai S, Huang X, Lin C, Zhu C, Hu Y, Mi S, Liu C. Activating PXR by Imperatorin Attenuates Dextran Sulphate Sodium-Induced Colitis in Mice. Br J Pharmacol. 2018 Jun 26. doi: 10.1111/bph.14424. [Epub ahead of print] PubMed PMID: 29945292.