TargetMol

Lavendamycin

Product Code:
 
TAR-T25642
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T25642-100mg100mgEnquire
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TAR-T25642-500mg500mgEnquire
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Further Information

Bioactivity:
Lavendamycin is a naturally occurring chemical isolated from fermentation broth of the soil bacterium Streptomyces lavendulae. It has antibiotic properties and significant anti-proliferative effects against several cancer cell lines.
CAS:
81645-09-2
Molecular Weight:
398.37
Purity:
0.98
SMILES:
O=C(O)C1=NC(C=2N=C3C(=O)C(N)=CC(=O)C3=CC2)=C4NC=5C=CC=CC5C4=C1C

References

Ramesh S, Nagarajan R. A formal synthesis of lavendamycin methyl ester, nitramarine, and their analogues: a Povarov approach. J Org Chem. 2013 Jan 18;78(2):545-58. doi: 10.1021/jo302389s. Epub 2012 Dec 20. PubMed PMID: 23215629. McElroy WT, DeShong P. Siloxane-based cross-coupling of bromopyridine derivatives: studies for the synthesis of streptonigrin and lavendamycin. Org Lett. 2003 Dec 11;5(25):4779-82. PubMed PMID: 14653672. Boger DL, Yasuda M, Mitscher LA, Drake SD, Kitos PA, Thompson SC. Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones. J Med Chem. 1987 Oct;30(10):1918-28. PubMed PMID: 3656364. Xia X, Lin S, Xia XX, Cong FS, Zhong JJ. Significance of agitation-induced shear stress on mycelium morphology and lavendamycin production by engineered Streptomyces flocculus. Appl Microbiol Biotechnol. 2014 May;98(10):4399-407. doi: 10.1007/s00253-014-5555-4. Epub 2014 Feb 13. PubMed PMID: 24522728.