TargetMol

Metkephamid acetate

Product Code:
 
TAR-T25804L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Metkephamid acetate is a synthetic opioid pentapeptide and derivative of [Met]enkephalin. It shows as a potent agonist of the δ- and u-opioid receptors with roughly equipotent affinity, and also has similarly high affinity as well as subtype-selectivity for the κ3-opioid receptor.
CAS:
66960-35-8
Molecular Weight:
660.79
Purity:
0.98
SMILES:
CC(O)=O.CSCC[C@H](N(C)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O

References

Burkhardt C, Frederickson RC, Pasternak GW. Metkephamid (Tyr-D-ala-Gly-Phe-N(Me)Met-NH2), a potent opioid peptide: receptor binding and analgesic properties. Peptides. 1982 Sep-Oct;3(5):869-71. PubMed PMID: 6294639. Pasanisi F, Sloan L, Rubin PC. Cardiovascular properties of metkephamid, a delta opioid receptor agonist, in man. Clin Sci (Lond). 1985 Feb;68(2):209-13. PubMed PMID: 2981652. Bloomfield SS, Barden TP, Mitchell J. Metkephamid and meperidine analgesia after episiotomy. Clin Pharmacol Ther. 1983 Aug;34(2):240-7. PubMed PMID: 6872419. Leander JD, Wood CR. Metkephamid effects on operant behavior. Peptides. 1982 Sep-Oct;3(5):771-3. PubMed PMID: 7177922.