TargetMol

Octicidine

Product Code:
 
TAR-T25896
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Octicidine is derived from phaseolotoxin by the removal of C-terminal dipeptide. It is a transition state analog that irreversibly suppresses ornithine carbamoyltransferase.
CAS:
65370-68-5
Molecular Weight:
291.22
Purity:
0.98
SMILES:
P(NCCC[C@@H](C(O)=O)N)(OS(N)(=O)=O)(=O)O

References

Langley DB, Templeton MD, Fields BA, Mitchell RE, Collyer CA. Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism. J Biol Chem. 2000 Jun 30;275(26):20012-9. Erratum in: J Biol Chem 2000 Sep 29;275(39):30746. PubMed PMID: 10747936. Templeton MD, Mitchell RE, Sullivan PA, Shepherd MG. The inactivation of ornithine transcarbamoylase by N delta-(N'-sulpho-diaminophosphinyl)-L-ornithine. Biochem J. 1985 Jun 1;228(2):347-52. PubMed PMID: 4015624; PubMed Central PMCID: PMC1144992. Hatziloukas E, Panopoulos NJ. Origin, structure, and regulation of argK, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase in Pseudomonas syringae pv. phaseolicola, and functional expression of argK in transgenic tobacco. J Bacteriol. 1992 Sep;174(18):5895-909. PubMed PMID: 1522066; PubMed Central PMCID: PMC207126. Templeton MD, Reinhardt LA, Collyer CA, Mitchell RE, Cleland WW. Kinetic analysis of the L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-N delta-(N'-sulfodiaminophosphinyl)-L-ornithine. Biochemistry. 2005 Mar 22;44(11):4408-15. PubMed PMID: 15766270.