TargetMol

Pepticinnamin E

Product Code:
 
TAR-T25939
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Pepticinnamin E is a naturally occurring bisubstrate farnesyltransferase inhibitor.
CAS:
147317-36-0
Molecular Weight:
908.43
Purity:
0.98
SMILES:
[C@H](CC1=C(Cl)C(O)=C(OC)C=C1)(C(N([C@@H](CC2=CC=CC=C2)C(OC[C@@H]3C(=O)NCC(=O)N3)=O)C)=O)N(C([C@@H](CC4=CC=C(O)C=C4)NC(/C=C/C5=C(/C=C\CCC)C=CC=C5)=O)=O)C

References

Shiomi K, Yang H, Inokoshi J, Van der Pyl D, Nakagawa A, Takeshima H, Omura S. Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. II. Structural elucidation of pepticinnamin E. J Antibiot (Tokyo). 1993 Feb;46(2):229-34. PubMed PMID: 8468236. Thutewohl M, Waldmann H. Solid-phase synthesis of a pepticinnamin E library. Bioorg Med Chem. 2003 Jun 12;11(12):2591-615. PubMed PMID: 12757726. Thutewohl M, Kissau L, Popkirova B, Karaguni IM, Nowak T, Bate M, Kuhlmann J, M?ller O, Waldmann H. Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library. Bioorg Med Chem. 2003 Jun 12;11(12):2617-26. PubMed PMID: 12757727. Hinterding K, Hagenbuch P, R?tey J, Waldmann H. Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E. Angew Chem Int Ed Engl. 1998 May 18;37(9):1236-1239. doi: 10.1002/(SICI)1521-3773(19980518)37:9<1236::AID-ANIE1236>3.0.CO;2-F. PubMed PMID: 29711232.