TargetMol

Polymyxin D2

Product Code:
 
TAR-T25972
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Polymyxin D2 is a cationic lipopeptide antibiotic against many species of Gram-negative bacteria.
CAS:
34167-45-8
Molecular Weight:
1130.34
Purity:
0.98
SMILES:
N(C([C@H](NC([C@@H](NC([C@@H](NC(CCCCC(C)C)=O)CCN)=O)[C@@H](C)O)=O)CO)=O)[C@@H]1C(=O)N[C@@H](CCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CCN)C(=O)N[C@@H](CCN)C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC1)[H])[H]

References

Shaheen M, Li J, Ross AC, Vederas JC, Jensen SE. Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chem Biol. 2011 Dec 23;18(12):1640-8. doi: 10.1016/j.chembiol.2011.09.017. PubMed PMID: 22195566. Gilleland HE Jr, Conrad RS. Chemical alterations in cell envelopes of polymyxin-resistant mutants of Pseudomonas aeruginosa grown in the absence or presence of polymyxin. Antimicrob Agents Chemother. 1982 Dec;22(6):1012-6. PubMed PMID: 6297381; PubMed Central PMCID: PMC185712. Iannazzo L, Sathananthan S, Majewski H. Modulation of dopamine release from rat striatum by protein kinase C: interaction with presynaptic D2-dopamine-autoreceptors. Br J Pharmacol. 1997 Dec;122(8):1561-6. PubMed PMID: 9422799; PubMed Central PMCID: PMC1565103. Jamrozik Z, De Yebenes JG, Troung DD, Cadet J. Intrastriatal infusion of amiloride increases rotations in 6-OHDA lesioned rats and "down-regulates" D2 receptors in the striatum and 5-HT2A receptors in the cortex. Pol J Pharmacol. 1994 Sep-Oct;46(5):417-22. PubMed PMID: 7894528.