TargetMol

Thiomandelic acid

Product Code:
 
TAR-T26271
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.
CAS:
04/09/4695
Molecular Weight:
168.213
Purity:
0.98
SMILES:
OC(=O)C(S)c1ccccc1

References

Karsisiotis AI, Damblon C, Roberts GC. Complete ?H, ??N, and ??C resonance assignments of Bacillus cereus metallo-?-lactamase and its complex with the inhibitor R-thiomandelic acid. Biomol NMR Assign. 2014 Oct;8(2):313-8. doi: 10.1007/s12104-013-9507-1. Epub 2013 Jul 10. PubMed PMID: 23838816; PubMed Central PMCID: PMC4145196. Mollard C, Moali C, Papamicael C, Damblon C, Vessilier S, Amicosante G, Schofield CJ, Galleni M, Frere JM, Roberts GC. Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. J Biol Chem. 2001 Nov 30;276(48):45015-23. Epub 2001 Sep 19. PubMed PMID: 11564740. Damblon C, Jensen M, Ababou A, Barsukov I, Papamicael C, Schofield CJ, Olsen L, Bauer R, Roberts GC. The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding. J Biol Chem. 2003 Aug 1;278(31):29240-51. Epub 2003 Apr 29. PubMed PMID: 12724330. Karsisiotis AI, Damblon CF, Roberts GC. Solution structures of the Bacillus cereus metallo-?-lactamase BcII and its complex with the broad spectrum inhibitor R-thiomandelic acid. Biochem J. 2013 Dec 15;456(3):397-407. doi: 10.1042/BJ20131003. PubMed PMID: 24059435; PubMed Central PMCID: PMC3898119.