TargetMol

Abroquinone A

Product Code:
 
TAR-T26523
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Abroquinone A, a natural isoflavanquinone, has been shown to block cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils, it may have pharmaceutical potential as an antiallergic agent.
CAS:
71593-10-7
Formula:
C19H20O7
Molecular Weight:
360.36
Purity:
0.98
SMILES:
O=C1C(=CC(=O)C(OC)=C1OC)[C@@H]2CC=3C(OC2)=CC(OC)=C(OC)C3

References

Wang JP, Hsu MF, Chang LC, Kuo JS, Kuo SC. Inhibition of plasma extravasation by abruquinone A, a natural isoflavanquinone isolated from Abrus precatorius. Eur J Pharmacol. 1995 Jan 24;273(1-2):73-81. PubMed PMID: 7537681. Hsu MF, Chang LC, Chen SC, Kuo SC, Lee HY, Lu MC, Wang JP. Blockade of cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils by a natural isoflavanquinone abruquinone A. Eur J Pharmacol. 2008 Nov 19;598(1-3):123-31. doi: 10.1016/j.ejphar.2008.09.007. Epub 2008 Sep 22. PubMed PMID: 18834875. Hsu MF, Raung SL, Tsao LT, Kuo SC, Wang JP. Cellular localization of the inhibitory action of abruquinone A against respiratory burst in rat neutrophils. Br J Pharmacol. 1997 Mar;120(5):917-25. PubMed PMID: 9138699; PubMed Central PMCID: PMC1564537. Hata Y, Raith M, Ebrahimi SN, Zimmermann S, Mokoka T, Naidoo D, Fouche G, Maharaj V, Kaiser M, Brun R, Hamburger M. Antiprotozoal isoflavan quinones from Abrus precatorius ssp. africanus. Planta Med. 2013 Apr;79(6):492-8. doi: 10.1055/s-0032-1328298. Epub 2013 Mar 19. PubMed PMID: 23512498.