TargetMol

AZ12971554

Product Code:
 
TAR-T26702
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T26702-100mg100mgEnquire
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TAR-T26702-500mg500mgEnquire
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Further Information

Bioactivity:
AZ12971554 is a potent inhibitor of human thrombin. Ki = 0.3nM, Activated partial thromboplastin time (APTT) IC50 = 0.68uM, Ecarin clotting time (ECT) IC50 = 0.16uM in human plasma.
CAS:
T26702
Molecular Weight:
457.85
Purity:
0.98
SMILES:
O=C([C@@H]1CC=NN1C([C@@H](C2=CC=C(F)C=C2)O)=O)NCC3=CC(Cl)=CC=C3N4N=NN=C4

References

Karlsson S, Branalt J, Halvarsson MO, Bergman J. (2014) A One-Pot Asymmetric Synthesis of a N Acylated 4,5- Dihydropyrazole, A Key Intermediate of Thrombin Inhibitor AZD8165. Organic Process Research and Development, 18: 969-975.