TargetMol

Azumamide E

Product Code:
 
TAR-T26731
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Azumamide E, a cyclotetrapeptide isolated from the sponge Mycale izuensis, is a carboxylic acid containing natural histone deacetylase (HDAC) inhibitor.
CAS:
585535-37-1
Molecular Weight:
514.623
Purity:
0.98
SMILES:
CC(C)C1NC(=O)[C@@H](C)[C@@H](C\C=C/CCC(O)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O |@:1|

References

Wen S, Carey KL, Nakao Y, Fusetani N, Packham G, Ganesan A. Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue. Org Lett. 2007 Mar 15;9(6):1105-8. Epub 2007 Feb 21. PubMed PMID: 17311393. Terracciano S, Di Micco S, Bifulco G, Gallinari P, Riccio R, Bruno I. Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222. Bioorg Med Chem. 2010 May 1;18(9):3252-60. doi: 10.1016/j.bmc.2010.03.022. Epub 2010 Mar 15. PubMed PMID: 20381359. Chandrasekhar S, Rao CL, Seenaiah M, Naresh P, Jagadeesh B, Manjeera D, Sarkar A, Bhadra MP. Total synthesis of azumamide E and sugar amino acid-containing analogue. J Org Chem. 2009 Jan 2;74(1):401-4. doi: 10.1021/jo8020264. PubMed PMID: 19053574. Maulucci N, Chini MG, Micco SD, Izzo I, Cafaro E, Russo A, Gallinari P, Paolini C, Nardi MC, Casapullo A, Riccio R, Bifulco G, Riccardis FD. Molecular insights into azumamide e histone deacetylases inhibitory activity. J Am Chem Soc. 2007 Mar 14;129(10):3007-12. Epub 2007 Feb 21. PubMed PMID: 17311384.