TargetMol

BB-3497

Product Code:
 
TAR-T26747
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
BB-3497, a potent inhibitor of Escherichia coli peptide deformylase, has antibacterial activity both in vitro and in vivo.
CAS:
235784-88-0
Molecular Weight:
329.43
Purity:
0.98
SMILES:
[C@H](C(N[C@H](C(N(C)C)=O)[C@@](C)(C)C)=O)(CN(C=O)O)CCCC

References

Guay DR. Drug forecast - the peptide deformylase inhibitors as antibacterial agents. Ther Clin Risk Manag. 2007 Aug;3(4):513-25. PubMed PMID: 18472972; PubMed Central PMCID: PMC2374925. Sharma A, Sharma S, Khuller GK, Kanwar AJ. In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv. Int J Antimicrob Agents. 2009 Sep;34(3):226-30. doi: 10.1016/j.ijantimicag.2009.04.005. Epub 2009 Jun 7. PubMed PMID: 19505802. Kumari T, Issar U, Kakkar R. Docking modes of BB-3497 into the PDF active site--a comparison of the pure MM and QM/MM based docking strategies. Curr Comput Aided Drug Des. 2014;10(4):315-26. PubMed PMID: 25994638. Sharma A, Khuller GK, Kanwar AJ, Sharma S. Therapeutic potential of peptide deformylase inhibitors against experimental tuberculosis. J Infect. 2010 Jun;60(6):498-501. doi: 10.1016/j.jinf.2010.03.009. Epub 2010 Mar 25. PubMed PMID: 20346970.