TargetMol

BI-44370

Product Code:
 
TAR-T26796
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T26796-100mg100mgEnquire
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TAR-T26796-500mg500mgEnquire
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Further Information

Bioactivity:
BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.
CAS:
866086-05-7
Molecular Weight:
633.78
Purity:
0.98
SMILES:
O=C1N(C2CCN(C(O[C@@H](C(=O)N3CCC(CC3)N4CCOCC4)CC5=CC(C)=C(O)C(C)=C5)=O)CC2)CCC=6C(N1)=CC=CC6

References

Negro A, Lionetto L, Simmaco M, Martelletti P. CGRP receptor antagonists: an expanding drug class for acute migraine? Expert Opin Investig Drugs. 2012 Jun;21(6):807-18. doi: 10.1517/13543784.2012.681044. Epub 2012 Apr 19. Review. PubMed PMID: 22512641. Diener HC, Barbanti P, Dahl?f C, Reuter U, Habeck J, Podhorna J. BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84. doi: 10.1177/0333102410388435. Epub 2010 Dec 20. PubMed PMID: 21172952. Hougaard A, Tfelt-Hansen P. Review of dose-response curves for acute antimigraine drugs: triptans, 5-HT1F agonists and CGRP antagonists. Expert Opin Drug Metab Toxicol. 2015;11(9):1409-18. doi: 10.1517/17425255.2015.1055244. Epub 2015 Jun 26. Review. PubMed PMID: 26095133. Palme O, Moszyk A, Iph?fer D, Lang S. Selected microbial glycolipids: production, modification and characterization. Adv Exp Med Biol. 2010;672:185-202. Review. PubMed PMID: 20545283.