TargetMol

BIBS-222

Product Code:
 
TAR-T26802
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat.
CAS:
142023-57-2
Molecular Weight:
638.58
Purity:
0.98
SMILES:
O=C(O)C=1C(Cl)=CC=C(Cl)C1C(=O)NC2=CC=C(C=C2)CN3C=4C=C(C=CC4N=C3CCCC)N(C(=O)NC)CCCCC

References

Zhang J, Pfaffendorf M, van Zwieten PA. Effect of various angiotensin receptor antagonists on cardiovascular responses to angiotensin II in pithed rats. J Cardiovasc Pharmacol. 1994 Jul;24(1):108-13. PubMed PMID: 7521474. Zhang JS, Van Meel JC, Pfaffendorf M, Van Zwieten PA. Different types of angiotensin II receptor antagonism induced by BIBS 222 in the rat portal vein and rabbit aorta; the influence of receptor reserve. J Pharmacol Exp Ther. 1994 May;269(2):509-14. PubMed PMID: 8182519. Zhang J, Pfaffendorf M, van Zwieten PA. Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits. J Cardiovasc Pharmacol. 1995 May;25(5):724-31. PubMed PMID: 7630151. Zhang JS, van Meel JC, Pfaffendorf M, van Zwieten PA. Inhibitory effect of dithiothreitol on angiotensin II-induced contractions mediated by AT1-receptors in rat portal vein and rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 1994 May;349(5):538-42. PubMed PMID: 8065468.