TargetMol

CZh226

Product Code:
 
TAR-T27115
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T27115-100mg100mgEnquire
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TAR-T27115-500mg500mgEnquire
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Further Information

Bioactivity:
CZh226 is a potent and selective PAK4 inhibitor (PAK4 Ki = 9 nM; PAK1 Ki = 3112 nM). CZh226 potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro.
CAS:
T27115
Formula:
C20H22ClN7O
Molecular Weight:
411.89
Purity:
0.98
SMILES:
O=C(N1C[C@@H](C)NCC1)C2=NC3=CC=C(Cl)C=C3C(NC4=NNC(C5CC5)=C4)=N2

References

Hao C, Zhao F, Song HY, Guo J, Li X, Jiang X, Huan R, Song S, Zhang Q, Wang R, Wang K, Pang Y, Liu T, Lu T, Huang W, Wang J, Lin B, He Z, Li H, Li F, Zhao D, Cheng M. Structure-based design of 6-chloro-4-aminoquinazoline-2-carboxamide derivatives as potent and selective p21-activated kinase 4 (PAK4) inhibitors. J Med Chem. 2017 Nov 30. doi: 10.1021/acs.jmedchem.7b01342. [Epub ahead of print] PubMed PMID: 29190083.