TargetMol

FMS586

Product Code:
 
TAR-T27345
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T27345-100mg100mgEnquire
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Further Information

Bioactivity:
FMS586 is a selective antagonist of neuropeptide Y Y5 receptor with oral activity.
CAS:
302556-51-0
Molecular Weight:
390.52
Purity:
0.98
SMILES:
O=C(NC=1C=CC2=C(C1)C3=C(N2C(C)C)CCCC3)N(C)CCC=4C=CN=CC4

References

Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H. Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethy l)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor. J Pharmacol Exp Ther. 2006 May;317(2):562-70. PubMed PMID: 16436501. Kakui N, Kitamura K. Direct evidence that stimulation of neuropeptide Y Y5 receptor activates hypothalamo-pituitary-adrenal axis in conscious rats via both corticotropin-releasing factor- and arginine vasopressin-dependent pathway. Endocrinology. 2007 Jun;148(6):2854-62. PubMed PMID: 17363455.