TargetMol

HLI98D

Product Code:
 
TAR-T27547
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1

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This product comes from: United States.
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Further Information

Bioactivity:
HLI98D is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.
Molecular Weight:
368.73
Purity:
0.98
SMILES:
[O-][N+](=O)c1ccc2n(-c3ccc(Cl)cc3)c3nc(=O)[nH]c(=O)c3cc2c1

References

Dou X, Li X, Tao L, Hu C, Zhang L, He Q, Yang B, Hu Y. Synthesis and biological evaluation of novel pyrimido[4,5-b]quinoline-2,4- dione derivatives as MDM2 ubiquitin ligase inhibitors. Med Chem. 2013 Jun 1;9(4):581-7. PubMed PMID: 22920093. Huang L, Hu B, Ni J, Wu J, Jiang W, Chen C, Yang L, Zeng Y, Wan R, Hu G, Wang X. Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis. J Exp Clin Cancer Res. 2016 Feb 4;35:27. doi: 10.1186/s13046-016-0301-7. PubMed PMID: 26847351; PubMed Central PMCID: PMC4743194. Yang Y, Ludwig RL, Jensen JP, Pierre SA, Medaglia MV, Davydov IV, Safiran YJ, Oberoi P, Kenten JH, Phillips AC, Weissman AM, Vousden KH. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005 Jun;7(6):547-59. PubMed PMID: 15950904. Chen H, Wu G, Gao S, Guo R, Zhao Z, Yuan H, Liu S, Wu J, Lu X, Yuan X, Yu Z, Zu X, Xie N, Yang N, Hu Z, Sun Q, Zhang W. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from ?-Santonin Derivatives. J Med Chem. 2017 Aug 2. doi: 10.1021/acs.jmedchem.6b01829. [Epub ahead of print] PubMed PMID: 28696694.