TargetMol

PAT-347 sodium

Product Code:
 
TAR-T28300
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T28300-100mg100mgEnquire
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TAR-T28300-500mg500mgEnquire
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Further Information

Bioactivity:
PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline.
CAS:
T28300
Molecular Weight:
560.98
Purity:
0.98
SMILES:
O=C(CN1C(C)=C(SC2=CC=CC(C(O[Na])=O)=C2F)C3=C1C(F)=C(Cl)C=C3)N4CC5(CC5)C6=CC=CC=C64

References

Structure?Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode Lisa M. MillerWillem-Jan KeuneDiana CastagnaLouise C. YoungEmma L. DuffyFrances PotjewydFernando Salgado-PoloPaloma Engel Garc?aDima SemaanJohn M. PritchardAnastassis PerrakisSimon J. F. MacdonaldCraig JamiesonAllan J. B. Watson Publication Date (Web): December 16, 2016 (Article) doi: 10.1021/acs.jmedchem.6b01597