TargetMol

PD 117302

Product Code:
 
TAR-T28313
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PD 117302 is a nonpeptide opioid compound. It is a selective kappa-opioid agonist. PD 117302 causes naloxone-reversible locomotor impairment and diuresis. It is an Anti-Arrhythmia Agent, an Anticonvulsants, a Cardiovascular Agent, and a Central Nervous System Agent.
CAS:
111728-01-9
Molecular Weight:
356.53
Purity:
0.98
SMILES:
N(C(CC1=C2C(SC=C2)=CC=C1)=O)(C)[C@H]3[C@@H](CCCC3)N4CCCC4

References

Porreca F, Ianone M, Wheeler H, Cowan A. Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats. Proc West Pharmacol Soc. 1989;32:185-7. PubMed PMID: 2550944. Leighton GE, Hill RG, Hughes J. The effects of the kappa agonist PD-117302 on feeding behaviour in obese and lean Zucker rats. Pharmacol Biochem Behav. 1988 Oct;31(2):425-9. PubMed PMID: 2854265. Leighton GE, Johnson MA, Meecham KG, Hill RG, Hughes J. Pharmacological profile of PD 117302, a selective kappa-opioid agonist. Br J Pharmacol. 1987 Dec;92(4):915-22. PubMed PMID: 2827830; PubMed Central PMCID: PMC1853714. Colombo M, Petrillo P, La Regina A, Bianchi G, Tavani A. In vitro binding profile and in vivo pharmacological properties of the K-opioid compound PD 117302. Res Commun Chem Pathol Pharmacol. 1991 Jun;72(3):295-306. PubMed PMID: 1658887.