TargetMol

Rifamycin SV

Product Code:
 
TAR-T28538
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Rifamycin SV, a natural antibiotic, blocks RNA-polymerase transcription initiation, modulating ?2m aggregation; inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis.
CAS:
15105-92-7
Molecular Weight:
697.778
Purity:
0.98
SMILES:
[H][C@]1(C)\C=C/C=C(/C)\C(\O)=N/c2cc(O)c3c4C(=O)[C@](C)(Oc4c(C)c(O)c3c2O)O\C=C/[C@]([H])(OC)[C@@]([H])(C)[C@@]([H])(OC(C)=O)[C@]([H])(C)[C@]([H])(O)[C@]([H])(C)[C@@]1([H])O |c:3,9,34,t:5|

References

Kimoto E, Bi YA, Kosa RE, Tremaine LM, Varma MVS. Hepatobiliary Clearance Prediction: Species Scaling from Monkey, Dog and Rat, and In Vitro-In Vivo Extrapolation of Sandwich Cultured Human Hepatocytes using 17 Drugs. J Pharm Sci. 2017 Apr 26. pii: S0022-3549(17)30279-4. doi: 10.1016/j.xphs.2017.04.043. [Epub ahead of print] PubMed PMID: 28456723. Narang SS, Shuaib S, Goyal B. Molecular insights into the inhibitory mechanism of rifamycin SV against ?(2)-microglobulin aggregation: A molecular dynamics simulation study. Int J Biol Macromol. 2017 Apr 25;102:1025-1034. doi: 10.1016/j.ijbiomac.2017.04.086. [Epub ahead of print] PubMed PMID: 28455257. Marcinko TM, Dong J, LeBlanc R, Daborowski KV, Vachet RW. Small Molecule-mediated Inhibition of ?-2-Microglobulin Amyloid Fibril Formation. J Biol Chem. 2017 May 3. pii: jbc.M116.774083. doi: 10.1074/jbc.M116.774083. [Epub ahead of print] PubMed PMID: 28468825. Bond TEH, Sorenson AE, Schaeffer PM. Functional characterisation of Burkholderia pseudomallei biotin protein ligase: A toolkit for anti-melioidosis drug development. Microbiol Res. 2017 Jun;199:40-48. doi: 10.1016/j.micres.2017.03.007. Epub 2017 Mar 19. PubMed PMID: 28454708.