TargetMol

SPM-242

Product Code:
 
TAR-T28838
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T28838-100mg100mgEnquire
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TAR-T28838-500mg500mgEnquire
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Further Information

Bioactivity:
SPM-242 is an orthosteric agonist of Sphingosine 1-phosphate (S1P) and a bitopic antagonist. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including vascular development and lymphocyte trafficking, by activating G protein-coupled receptors for S1P, namely, S1P(1) through S1P(5).
CAS:
T28838
Molecular Weight:
419.81
Purity:
0.98
SMILES:
OC1=CC=CC(SC2=CC=C(CC[C@@](CO)(OP(O)(O)=O)N)C(Cl)=C2)=C1

References

Jo E, Bhhatarai B, Repetto E, Guerrero M, Riley S, Brown SJ, Kohno Y, Roberts E, Sch?rer SC, Rosen H. Novel selective allosteric and bitopic ligands for the S1P(3) receptor. ACS Chem Biol. 2012 Dec 21;7(12):1975-83. doi: 10.1021/cb300392z. PubMed PMID: 22971058; PubMed Central PMCID: PMC3528827.