TargetMol

SRA880 free base

Product Code:
 
TAR-T28851
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 receptors. SRA880 positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test.
CAS:
187218-90-2
Molecular Weight:
464.56
Purity:
0.98
SMILES:
CN1[C@]2([C@@](CC=3C(C2)=CC=CC3OC)(C[C@@H](C(=O)N4CCN(CC4)C5=CC=C(N(=O)=O)C=C5)C1)[H])[H]

References

Nilsson A, Stroth N, Zhang X, Qi H, F?lth M, Sk?ld K, Hoyer D, Andr?n PE, Svenningsson P. Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects. Neuropharmacology. 2012 Jan;62(1):347-57. doi: 10.1016/j.neuropharm.2011.08.004. Epub 2011 Aug 16. PubMed PMID: 21856315. Marazioti A, Pitychoutis PM, Papadopoulou-Daifoti Z, Spyraki C, Thermos K. Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum. Psychopharmacology (Berl). 2008 Dec;201(3):413-22. doi: 10.1007/s00213-008-1305-6. Epub 2008 Sep 3. PubMed PMID: 18766330. Foong JP, Parry LJ, Gwynne RM, Bornstein JC. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G384-94. doi: 10.1152/ajpgi.00438.2009. Epub 2009 Dec 10. PubMed PMID: 20007849; PubMed Central PMCID: PMC2838515. De Bundel D, Aourz N, Kiagiadaki F, Clinckers R, Hoyer D, Kastellakis A, Michotte Y, Thermos K, Smolders I. Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. Neuroreport. 2010 Mar 10;21(4):254-8. doi: 10.1097/WNR.0b013e3283353a64. PubMed PMID: 20134357.