TargetMol

TRC-19

Product Code:
 
TAR-T29003
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T29003-100mg100mgEnquire
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TAR-T29003-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
TRC-19 is a potent and selective inhibitor of Toxoplasma gondii dihydrofolate reductase. TRC-19 shows an IC50 of 9 nM and 89-fold selectivity in favor of Toxoplasma gondii dihydrofolate reductase.
CAS:
T29003
Molecular Weight:
346.44
Purity:
0.98
SMILES:
NC1=C(N2CCN(C3=CC(C4=CC=CC=C4)=CC=C3)CC2)C=NC(N)=N1

References

Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design Matthew E. Welsch, Jian Zhou, Yueqiang Gao, Yunqing Yan, Gene Porter, Gautam Agnihotri, Yingjie Li, Henry Lu, Zhongguo Chen, and Stephen B. Thomas Publication Date (Web): September 17, 2016 (Letter) doi: 10.1021/acsmedchemlett.6b00328