TargetMol

Candoxatrilat

Product Code:
 
TAR-T30701
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T30701-100mg100mgEnquire
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TAR-T30701-500mg500mgEnquire
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Further Information

Bioactivity:
Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation.
CAS:
123122-54-3
Molecular Weight:
399.48
Purity:
0.98
SMILES:
C([C@@H](COCCOC)C(O)=O)C1(C(N[C@H]2CC[C@@H](C(O)=O)CC2)=O)CCCC1

References

Kaye B, Brearley CJ, Cussans NJ, Herron M, Humphrey MJ, Mollatt AR. Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril. Xenobiotica. 1997 Oct;27(10):1091-102. PubMed PMID: 9364744. Barclay PL, Bennett JA, Samuels GM, Shepperson NB. The atriopeptidase inhibitor (+/-) candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action. Biochem Pharmacol. 1991 Mar 1;41(5):841-4. PubMed PMID: 1847819. Barclay PL, Bennett JA, Greengrass PM, Griffin A, Samuels GM, Shepperson NB. The pharmacokinetics of 125I-atrial natriuretic factor in anaesthetized rats. Effects of neutral endopeptidase inhibition with candoxatrilat and of ANF-C receptor blockade. Biochem Pharmacol. 1992 Sep 25;44(6):1013-22. PubMed PMID: 1417928.