TargetMol

Daunorubicinol

Product Code:
 
TAR-T31209
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Daunorubicinol is the main metabolite of daunomycin.
CAS:
28008-55-1
Molecular Weight:
529.54
Purity:
0.98
SMILES:
OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@]([C@H](C)O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5

References

Callies S, de Alwis DP, Mehta A, Burgess M, Aarons L. Population pharmacokinetic model for daunorubicin and daunorubicinol coadministered with zosuquidar.3HCl (LY335979). Cancer Chemother Pharmacol. 2004 Jul;54(1):39-48. Epub 2004 Mar 24. PubMed PMID: 15045528. Cusack BJ, Young SP, Olson RD. Daunorubicin and daunorubicinol pharmacokinetics in plasma and tissues in the rat. Cancer Chemother Pharmacol. 1995;35(3):213-8. PubMed PMID: 7805179. Platel D, Bonoron-Ad?le S, Robert J. Role of daunorubicinol in daunorubicin-induced cardiotoxicity as evaluated with the model of isolated perfused rat heart. Pharmacol Toxicol. 2001 May;88(5):250-4. PubMed PMID: 11393585. Cusack BJ, Young SP, Vestal RE, Olson RD. Age-related pharmacokinetics of daunorubicin and daunorubicinol following intravenous bolus daunorubicin administration in the rat. Cancer Chemother Pharmacol. 1997;39(6):505-12. PubMed PMID: 9118462.