TargetMol

Dehydroretrorsine

Product Code:
 
TAR-T31367
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Dehydroretrorsine is a pyrrolizidine alkaloid metabolite.
CAS:
23092-97-9
Formula:
C18H23NO6
Molecular Weight:
349.383
Purity:
0.98
SMILES:
[H][C@]12CCn3ccc(COC(=O)[C@@](O)(CO)[C@H](C)C\C(=C\C)C(=O)O1)c23

References

Mattocks AR, Jukes R. Trapping and measurement of short-lived alkylating agents in a recirculating flow system. Chem Biol Interact. 1990;76(1):19-30. PubMed PMID: 2393942. Zhao Y, Xia Q, Yin JJ, Lin G, Fu PP. Photoirradiation of dehydropyrrolizidine alkaloids--formation of reactive oxygen species and induction of lipid peroxidation. Toxicol Lett. 2011 Sep 10;205(3):302-9. doi: 10.1016/j.toxlet.2011.06.020. Epub 2011 Jun 22. PubMed PMID: 21723383. Weidner MF, Sigurdsson ST, Hopkins PB. Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5'-CG by structurally simplified analogues of mitomycin C. Biochemistry. 1990 Oct 2;29(39):9225-33. PubMed PMID: 2125476. Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Veps?l?inen J, Pasanen M. Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol. Chem Res Toxicol. 2014 Nov 17;27(11):1950-7. doi: 10.1021/tx5002964. Epub 2014 Oct 21. PubMed PMID: 25295702.