TargetMol

Dezaguanine

Product Code:
 
TAR-T31406
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Dezaguanine is a novel antipurine antimetabolite with significant activity against transplantable rodent solid tumors, particularly breast adenocarcinoma.
CAS:
41729-52-6
Molecular Weight:
150.14
Purity:
0.98
SMILES:
O=C1NC(N)=CC=2NC=NC12

References

Bruender NA, Young AP, Bandarian V. Correction to Chemical and Biological Reduction of the Radical SAM Enzyme 7-Carboxy-7-deazaguanine Synthase. Biochemistry. 2016 Mar 29;55(12):1939. doi: 10.1021/acs.biochem.6b00147. Epub 2016 Mar 7. PubMed PMID: 26950390. Rinaldi AJ, Lund PE, Blanco MR, Walter NG. The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts. Nat Commun. 2016 Jan 19;7:8976. doi: 10.1038/ncomms9976. PubMed PMID: 26781350; PubMed Central PMCID: PMC4735710. Smee DF, Evans WJ, Nicolaou KC, Tarbet EB, Day CW. Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds. Antiviral Res. 2016 Jul;131:61-5. doi: 10.1016/j.antiviral.2016.04.003. Epub 2016 Apr 7. PubMed PMID: 27063860. Thiaville JJ, Kellner SM, Yuan Y, Hutinet G, Thiaville PC, Jumpathong W, Mohapatra S, Brochier-Armanet C, Letarov AV, Hillebrand R, Malik CK, Rizzo CJ, Dedon PC, de Cr?cy-Lagard V. Novel genomic island modifies DNA with 7-deazaguanine derivatives. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1452-9. doi: 10.1073/pnas.1518570113. Epub 2016 Feb 29. PubMed PMID: 26929322; PubMed Central PMCID: PMC4801273.