Ingenol disoxate

Product Code:

TAR-T32162

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20°C

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Code	Size	Price

TAR-T32162-100mg

100mg

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TAR-T32162-500mg

500mg

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Further Information

Bioactivity:

Ingenol disoxate, also known as LEO43204, is a Novel 4-Isoxazolecarboxylate Ester of Ingenol with Improved Properties for Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers. Ingenol is a natural product found in the sap of the plant Euphorbia peplus and an inducer of cell death.

CAS:

1383547-60-1

Molecular Weight:

499.6

Purity:

0.98

SMILES:

O[C@@]12[C@@]3(C(=O)[C@]([C@]4([C@@](C[C@H]3C)(C4(C)C)[H])[H])(C=C(CO)[C@H]1O)[H])C=C(C)[C@@H]2OC(=O)C=5C(CC)=NOC5CC

Documents

References

Sinnya S, Tan JM, Prow TW, Primiero C, McEniery E, Selmer J, ?sterdal ML, Soyer HP. A randomized, phase IIa exploratory trial to assess the safety and preliminary efficacy of LEO 43204 in patients with actinic keratosis. Br J Dermatol. 2016 Feb;174(2):305-11. doi: 10.1111/bjd.14245. PubMed PMID: 26499175. Bertelsen M, Stahlhut M, Grue-S?rensen G, Liang X, Christensen GB, Skak K, Engell KM, H?gberg T. Ingenol Disoxate: A Novel 4-Isoxazolecarboxylate Ester of Ingenol with Improved Properties for Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers. Dermatol Ther (Heidelb). 2016 Dec;6(4):599-626. PubMed PMID: 27503482.