TargetMol

JH-IX-179

Product Code:
 
TAR-T32288
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autophosphorylation of FLT3 and activity of downstream signaling molecules of FLT3-D835Y and FLT3-ITD.
CAS:
T32288
Molecular Weight:
436.52
Purity:
0.98
SMILES:
O=C1C2=C(NC3=C2C=CC(C4=CNN=C4)=C3)C5=C1C=CC(C6=CN(CCCN(C)C)N=C6)=C5

References

Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor. John M. Hatcher, Ellen Weisberg, Taebo Sim, Richard M. Stone, Suiyang Liu, James D. Griffin, and Nathanael S. Gray. Publication Date (Web): March 8, 2016 (Letter). DOI: 10.1021/acsmedchemlett.5b00498