TargetMol

Neurokinin A (4-10), nle(10)-

Product Code:
 
TAR-T33653
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Neurokinin A (4-10), nle(10)- is a neurologically active peptide translated from the pre-protachykinin gene. Neurokinin A has many excitatory effects on mammalian nervous systems and on the mammalian inflammatory and pain responses.
CAS:
110863-33-7
Molecular Weight:
748.87
Purity:
0.98
SMILES:
[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCC)C(N)=O)=O)CC(C)C)=O)=O)C(C)C)=O)NC([C@@H](NC([C@H](CC(O)=O)N)=O)CO)=O

References

Naline E, Devillier P, Drapeau G, Toty L, Bakdach H, Regoli D, Advenier C. Characterization of neurokinin effects and receptor selectivity in human isolated bronchi. Am Rev Respir Dis. 1989 Sep;140(3):679-86. PubMed PMID: 2476956. Dougherty PM, Palecek J, Paleckov? V, Willis WD. Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin. J Neurophysiol. 1994 Oct;72(4):1464-75. PubMed PMID: 7823080. Patak EN, Ziccone S, Story ME, Fleming AJ, Lilley A, Pennefather JN. Activation of neurokinin NK(2) receptors by tachykinin peptides causes contraction of uterus in pregnant women near term. Mol Hum Reprod. 2000 Jun;6(6):549-54. PubMed PMID: 10825373. Warner FJ, Miller RC, Burcher E. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6. PubMed PMID: 12110377.