TargetMol

Paclitaxel-Succinic acid

Product Code:
 
TAR-T33862
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Paclitaxel-Succinic acid (paclitaxel-succinate , paclitaxel-semisucinic acid)is a paclitaxel derivative with a succinic acid linker. Paclitaxel-Succinic acid can be used to prepare paclitaxel conjugates for drug delivery and nanomedicine research.
CAS:
117527-50-1
Molecular Weight:
953.98
Purity:
0.98
SMILES:
O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)OC(CCC(O)=O)=O)=O)C5)[H]

References

Yin S, Huai J, Chen X, Yang Y, Zhang X, Gan Y, Wang G, Gu X, Li J. Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid. Acta Biomater. 2015 Oct 15;26:274-85. doi: 10.1016/j.actbio.2015.08.029. Epub 2015 Aug 20. PubMed PMID: 26300335. Yan Q, Yang Y, Chen W, Hu J, Yang D. Construction of polymer-paclitaxel conjugate linked via a disulfide bond. Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:580-5. doi: 10.1016/j.msec.2015.09.025. Epub 2015 Sep 10. PubMed PMID: 26478347. Wu D, Zheng Y, Hu X, Fan Z, Jing X. Anti-tumor activity of folate targeted biodegradable polymer-paclitaxel conjugate micelles on EMT-6 breast cancer model. Mater Sci Eng C Mater Biol Appl. 2015 Aug;53:68-75. doi: 10.1016/j.msec.2015.04.012. Epub 2015 Apr 14. PubMed PMID: 26042692. He X, Lin M, Lu T, Qu Z, Xu F. Molecular analysis of interactions between a PAMAM dendrimer-paclitaxel conjugate and a biomembrane. Phys Chem Chem Phys. 2015 Nov 28;17(44):29507-17. doi: 10.1039/c5cp02242h. Epub 2015 Aug 10. PubMed PMID: 26256278.