TargetMol

PhTX-343 TFA

Product Code:
 
TAR-T34056
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PhTX-343, also known as Philanthotoxin 343, is synthetic analogue of Philanthotoxin 433. PhTX-343 blocks NMDA-gated ion channels; synthetic analog of the wasp polyamine amide toxin δ-philanthotoxin.
CAS:
115976-93-7
Molecular Weight:
435.613
Purity:
0.98
SMILES:
CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCNCCCCNCCCN

References

Franzyk H, Grzeskowiak JW, Tikhonov DB, Jaroszewski JW, Mellor IR. The effects of conformational constraints in the polyamine moiety of philanthotoxins on AMPAR inhibition. ChemMedChem. 2014 Aug;9(8):1725-31. doi: 10.1002/cmdc.201402109. Epub 2014 Jul 8. PubMed PMID: 25044789. Kachel HS, Patel RN, Franzyk H, Mellor IR. Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition. Sci Rep. 2016 Nov 30;6:38116. doi: 10.1038/srep38116. PubMed PMID: 27901080; PubMed Central PMCID: PMC5128878. Fr?lund S, Bella A, Kristensen AS, Ziegler HL, Witt M, Olsen CA, Str?mgaard K, Franzyk H, Jaroszewski JW. Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists. J Med Chem. 2010 Oct 28;53(20):7441-51. doi: 10.1021/jm100886h. PubMed PMID: 20873775. McClymont DW, Harris J, Mellor IR. Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors. Eur J Pharmacol. 2012 Jul 5;686(1-3):22-31. doi: 10.1016/j.ejphar.2012.04.036. Epub 2012 Apr 27. PubMed PMID: 22564863; PubMed Central PMCID: PMC3657159.