TargetMol

RM-133

Product Code:
 
TAR-T34335
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
RM-133 is a promising pro-apoptotic agent which shows activity on various cancer cell lines.
CAS:
T34335
Molecular Weight:
652.88
Purity:
0.98
SMILES:
O=C(N1CCN([C@H]2C[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@](O)(C#C)CC[C@@]5([H])[C@]4([H])CC[C@@]3([H])C[C@@H]2O)CC1)[C@H]6N(C(C7=NC8=CC=CC=C8C=C7)=O)CCC6

References

Perreault M, Maltais R, Roy J, Dutour R, Poirier D. Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. ChemMedChem. 2017 Jan 20;12(2):177-182. doi: 10.1002/cmdc.201600482. Epub 2017 Jan 6. PubMed PMID: 28060448. Dutour R, Maltais R, Perreault M, Roy J, Poirier D. Parallel Solid-Phase Synthesis Using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines. Anticancer Agents Med Chem. 2018 Mar 7. doi: 10.2174/1871520618666180307130158. [Epub ahead of print] PubMed PMID: 29521249. Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D. Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model. Invest New Drugs. 2018 Jul 30. doi: 10.1007/s10637-018-0643-4. [Epub ahead of print] PubMed PMID: 30062573. Perreault M, Maltais R, Kenmogne LC, L?tourneau D, LeHoux JG, Gobeil S, Poirier D. Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133. Pharmacol Res. 2018 Feb;128:52-60. doi: 10.1016/j.phrs.2017.12.024. Epub 2017 Dec 26. PubMed PMID: 29287690.