TargetMol

Selenodiglutathione

Product Code:
 
TAR-T34605
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Selenodiglutathione is a primary Se metabolite conjugated with two glutathione (GSH) moieties.
CAS:
33944-90-0
Molecular Weight:
691.6
Purity:
0.98
SMILES:
N[C@@H](CCC(=O)N[C@@H](CS[Se]SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O

References

Tobe T, Ueda K, Ando M, Okamoto Y, Kojima N. Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells. J Biol Inorg Chem. 2015 Jun;20(4):687-94. doi: 10.1007/s00775-015-1254-6. Epub 2015 Mar 18. PubMed PMID: 25783495. Tobe T, Ueda K, Aoki A, Okamoto Y, Kojima N, Jinno H. Selenium uptake through cystine transporter mediated by glutathione conjugation. J Toxicol Sci. 2017;42(1):85-91. doi: 10.2131/jts.42.85. PubMed PMID: 28070112. Fisher B, Yarmolinsky D, Abdel-Ghany S, Pilon M, Pilon-Smits EA, Sagi M, Van Hoewyk D. Superoxide generated from the glutathione-mediated reduction of selenite damages the iron-sulfur cluster of chloroplastic ferredoxin. Plant Physiol Biochem. 2016 Sep;106:228-35. doi: 10.1016/j.plaphy.2016.05.004. Epub 2016 May 9. PubMed PMID: 27182957. Qiao Y, Huang X, Chen B, He M, Hu B. In vitro study on antagonism mechanism of glutathione, sodium selenite and mercuric chloride. Talanta. 2017 Aug 15;171:262-269. doi: 10.1016/j.talanta.2017.04.074. Epub 2017 May 5. PubMed PMID: 28551139.