TargetMol

SST-02

Product Code:
 
TAR-T34707
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
SST-02 is a potent cationic lipid for siRNA-Lipid Nanoparticles. SST-02 possesses a simple chemical structure and is synthesized just in one step. SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02 LNP did not show changes in body weight, blood chemistry, or hematological parameters, while the AST level decreased at a dose of 5 mg/kg. The use of SST-02 avoids a lengthy synthetic route and may thus decrease the future cost of nucleic acid therapeutics.
CAS:
T34707
Molecular Weight:
572.02
Purity:
0.98
SMILES:
CCCCC/C=C\C/C=C\CCCCCCCCN(CCCO)CCCCCCCC/C=C\C/C=C\CCCCC

References

Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles Takeshi Kuboyama, Kaori Yagi, Tomoyuki Naoi, Tomohiro Era, Nobuhiro Yagi, Yoshisuke Nakasato, Hayato Yabuuchi, Saori Takahashi, Fumikazu Shinohara, Hiroto Iwai, Ayumi Koubara-Yamada, Kazumasa Hasegawa, and Atsushi Miwa Publication Date (Web): April 12, 2019 (Letter) doi: 10.1021/acsmedchemlett.8b00652