TargetMol

Talaumidin

Product Code:
 
TAR-T34778
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T34778-500mg500mgEnquire
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Further Information

Bioactivity:
Talaumidin is a natural neurotrophic agent which promotes neurite outgrowth from neurons through the PI3K/Akt pathway.
CAS:
T34778
Formula:
C20H22O5
Molecular Weight:
342.39
Purity:
0.98
SMILES:
COC1=C(O)C=CC([C@H]2O[C@H](C3=CC4=C(OCO4)C=C3)[C@@H](C)[C@@H]2C)=C1

References

Koriyama Y, Furukawa A, Sugitani K, Kubo M, Harada K, Fukuyama Y. Talaumidin Promotes Neurite Outgrowth of Staurosporine-Differentiated RGC-5 Cells Through PI3K/Akt-Dependent Pathways. Adv Exp Med Biol. 2018;1074:649-653. doi: 10.1007/978-3-319-75402-4_79. PubMed PMID: 29721999. Harada K, Kubo M, Horiuchi H, Ishii A, Esumi T, Hioki H, Fukuyama Y. Systematic Asymmetric Synthesis of All Diastereomers of (-)-Talaumidin and Their Neurotrophic Activity. J Org Chem. 2015 Jul 17;80(14):7076-88. doi: 10.1021/acs.joc.5b00945. Epub 2015 Jul 6. PubMed PMID: 26108800. Harada K, Zaha K, Bando R, Irimaziri R, Kubo M, Koriyama Y, Fukuyama Y. Structure-activity relationships of talaumidin derivatives: Their neurite-outgrowth promotion in vitro and optic nerve regeneration in vivo. Eur J Med Chem. 2018 Mar 25;148:86-94. doi: 10.1016/j.ejmech.2018.02.014. Epub 2018 Feb 9. PubMed PMID: 29454919. Xue P, Wang LP, Jiao XZ, Jiang YJ, Xiao Q, Luo ZG, Xie P, Liang XT. Total synthesis of (-)-talaumidin and (-)-galbelgin. J Asian Nat Prod Res. 2009;11(3):281-7. doi: 10.1080/10286020802675191. PubMed PMID: 19408154.