TargetMol

TRK-380

Product Code:
 
TAR-T34958
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-T34958-100mg100mgEnquire
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TAR-T34958-500mg500mgEnquire
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Further Information

Bioactivity:
TRK-380 (TAC-301) is an effective and selective β3-adrenergic receptor agonist. TRK-380 improves formalin-induced frequent urination in rats and carbachol-induced bladder contraction in dogs (a decrease of 37.6%).
CAS:
T34958
Purity:
0.98
SMILES:
Unknown

References

Kanie S, Otsuka A, Yoshikawa S, Morimoto T, Hareyama N, Okazaki S, Kobayashi R, Hasebe K, Nakao K, Hayashi R, Mochizuki H, Matsumoto R, Ozono S. Pharmacological effect of TRK-380, a novel selective human ?3-adrenoceptor agonist, on mammalian detrusor strips. Urology. 2012 Mar;79(3):744.e1-7. doi: 10.1016/j.urology.2011.08.080. Epub 2011 Dec 23. PubMed PMID: 22197203. Kanie S, Otsuka A, Yoshikawa S, Kobayashi R, Itaba S, Yokokawa H, Tajima Y, Ozono S, Hayashi R, Mochizuki H. TRK-380, a novel selective human ?3-adrenoceptor agonist, ameliorates formalin-induced pollakiuria in rats and carbachol-induced bladder contraction in dogs. Urology. 2013 Oct;82(4):975.e7-975.e12. doi: 10.1016/j.urology.2013.07.016. PubMed PMID: 24075004. Thiagamoorthy G, Giarenis I, Cardozo L. Early investigational ?3 adreno-receptor agonists for the management of the overactive bladder syndrome. Expert Opin Investig Drugs. 2015;24(10):1299-306. doi: 10.1517/13543784.2015.1076390. Epub 2015 Aug 14. PubMed PMID: 26292923. Matsumoto R, Otsuka A, Suzuki T, Shinbo H, Mizuno T, Kurita Y, Mugiya S, Ozono S. Expression and functional role of ?3 -adrenoceptors in the human ureter. Int J Urol. 2013 Oct;20(10):1007-14. doi: 10.1111/iju.12093. Epub 2013 Jan 29. PubMed PMID: 23360304.