TargetMol

Acetyl-Hirudin (54-65) (sulfated)

Product Code:
 
TAR-T38645
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Acetyl-Hirudin (54-65) (sulfated) directly binds to thrombin-rHCII(L444R) and hinders the interaction between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin, which stabilizes the complex.
CAS:
125441-00-1
Molecular Weight:
1590.63
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(OS(O)(=O)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O

References

J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9.